Botox isn't just for cosmetics. Payers will cover therapeutic Botox but will deny any claim that lacks clear medical necessity. The key is separating cosmetic use from billable therapeutic procedures for conditions like hyperhidrosis, migraines, or blepharospasm.

Key Therapeutic Botox Codes

CPT 64650 / 64653 (Hyperhidrosis):

• Chemodenervation of eccrine glands in axillae (64650) or other areas like palms (64653).
• Requires prior authorization and documentation of failed conservative treatments (e.g., topicals like Drysol).

CPT 64615 (Chronic Migraine): Chemodenervation for prophylaxis of chronic migraine. Payers have very strict criteria (e.g., 15+ headache days per month).

CPT 64612 (Blepharospasm): Chemodenervation of muscles for blepharospasm, unilateral. Often requires documentation of visual disturbance.

Proving Medical Necessity

• Prior Authorization: This is non-negotiable for therapeutic Botox.
• Documentation: Your notes must clearly list failed conservative therapies, the functional impairment (e.g., "unable to hold a pen due to hyperhidrosis"), and the specific ICD-10 code (e.g., L74.51x for hyperhidrosis, G43.7x for chronic migraine).
• Drug Billing (J-Code): You must also bill for the drug itself (e.g., J0585 for Botox), billing the precise number of units injected.

The Cosmetic Trap